PHARMACOLOGY

Framycetin, a broad-spectrum amino glycoside antibiotic, is usually bactericidal in action. Although the exact mechanism of action has not been fully elucidated, the drug appears to inhibit protein synthesis in susceptible bacteria by binding to ribosomal subunits. In general, framycetin is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria. The drug is inactive against fungi, viruses, and most anaerobic bacteria.

Gramicidin is a cyclic polyceptide antibiotic. It alters the cation content of the bacterial cell wall. Gramicidin is primarily effective against gram-positive organisms.

INDICATIONS

For local use in the treatment of infections caused by pyogenic organisms, in particular S. aureus, the proteus group of bacteria, coliforms and P. aeruginosa. The treatment of bacterial infections of the skin and mucous membrane caused by susceptible bacteria. These include such conditions as pyoderma, folliculitis, paronychia, sycosis barbae, and impetigo. Also useful in controlling secondary bacterial infections in skin carcinoma, burns, eczemas, contact dermatitis, seborrhea, acne, psoriasis, varicose ulcers, and neurodermatitis.

CONTRAINDICATIONS

Sensitivity to framycetin. Framycetin should never be administered either i.v. or i.m. in view of the risk of irreversible ototoxicity or reversible nephrotoxicity.

PRECAUTIONS

Cross sensitization may occur among the group of Streptomyces derived antibiotics (neomycin, paromomycin, kanamycin) of which framycetin is a member, but this is not invariable. Prolonged use of antibiotics may result in the overgrowth of nonsusceptible organisms, including fungi. Appropriate measures should be taken if this occurs.

Apply locally 2 to 4 times a day as prescribed.

AVAILABILITY OF DOSAGE FORMS

Each g of ointment contains: framycetin sulfate BP 15 mg (1.5%), gramicidin 50 µg (0.005%) and anhydrous lanolin 10%. Tubes of 15 g.

STORAGE