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PHARMACOLOGY
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Framycetin, a broad-spectrum amino glycoside antibiotic, is usually bactericidal in action. Although the exact mechanism of action has not been fully elucidated, the drug appears to inhibit protein synthesis in susceptible bacteria by binding to ribosomal subunits. In general, framycetin is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria. The drug is inactive against fungi, viruses, and most anaerobic bacteria.
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INDICATIONS
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For local use in the treatment of infections
caused by pyogenic organisms, in particular S. aureus, the proteus group
of bacteria, coliforms and P. aeruginosa.
Treatment of bacterial blepharitis, conjunctivitis, styes, corneal abrasions and burns; prophylactically following removal of foreign bodies; corneal ulcers (sole treatment or as an adjunct to subconjunctival injection of framycetin). |
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CONTRAINDICATIONS
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Sensitivity to framycetin.
Framycetin should never be administered either i.v. or i.m. in view of the risk of irreversible ototoxicity or reversible nephrotoxicity.
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PRECAUTIONS
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Cross sensitization may occur among the group of Streptomyces derived antibiotics (neomycin, paromomycin, kanamycin) of which framycetin is a member, but this is not invariable. Prolonged use of antibiotics may result in the overgrowth of nonsusceptible organisms, including fungi. Appropriate measures should be taken if this occurs.
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DOSAGE AND ADMINISTRATION
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Ointment for continued effect: 2 or 3 applications daily, or at bedtime if drops have been used during the day.
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AVAILABILITY OF DOSAGE FORMS
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Each g of ointment contains: framycetin sulfate BP 5 mg in a sterile greasy ointment base. The ointment base is Plastibase 30W.
Tubes of 5 g.
Store all Soframycin products at controlled room temperature.
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STORAGE
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Store between 15° and 25°C
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